Medicinal Cannabis Effects: Why it’s Important to Understand the Biphasic, Acute, and Chronic Effects of Cannabis

Introduction

When a compound has biphasic effects it means that low and high doses of the same compound can have very different effects. Have you ever noticed how caffeine or exercise affects you differently depending on the amount? A small cup of coffee can sharpen your focus, but too much might leave you jittery. Similarly, a short jog can energise you, but overdo it, and you might feel exhausted instead of refreshed. Cannabis works in much the same way, thanks to what’s called the Biphasic Effect. 

This concept, coupled with the knowledge that different individuals have different innate sensitivities to cannabinoids, means that a dose that is calming for one individual can be overwhelming for another.

By understanding how this works, you can better tailor your medicinal cannabis use, optimise its benefits, and feel confident about incorporating it into your wellness journey.

Acute vs Chronic use, on the other hand, means a slightly different thing. Depending on how much you use and how often, the same plant can produce very different outcomes. Small doses might help you feel relaxed, focused, or creative, while larger doses – or prolonged use – can lead to diminishing benefits or even unwanted side effects.

Understanding these effects is key to tailoring your medicinal cannabis use for the best results while avoiding pitfalls. Intrigued? Let’s dive into the fascinating world of cannabis science and discover how to use it as a powerful tool for your wellness.

Understanding Acute Cannabis Use

In small or occasional doses, cannabis acts as a neural stimulant. Here’s what that means for you:

• Boosted Creativity and Relaxation: Many people report feeling more relaxed, focused, or even inspired after using small amounts of cannabis.
• Therapeutic Benefits: Whether you’re managing pain or anxiety, acute use often aligns with therapeutic goals, offering relief without overloading your system.

Understanding Chronic or Heavy Cannabis Use

Prolonged or heavy use of cannabis can shift its effects. Over time, your brain may adapt to maintain balance, which can:

• Reduce Synaptic Density: This means fewer connections between neurons, a natural adjustment to avoid overstimulation but one that might reduce cannabis’ overall effects.
• Downregulate Receptors: Your brain may decrease the activity or number of cannabinoid receptors, making cannabis less effective with frequent use.
• Impact Cognition and Mood: Chronic use could dull some of cannabis’ benefits, emphasizing the importance of breaks and balanced usage.

Understanding the Biphasic Effects of Cannabis

The term “biphasic” describes substances that elicit contrasting effects based on the dose or duration of exposure.

Let’s break this down. Think of caffeine: a single cup of coffee can perk you up and help you focus, but too much might leave you jittery and unable to concentrate. Cannabis works similarly – its effects depend on the dose. In small amounts, it can enhance neural activity and help you feel more in control. But if you use too much or too often, your body starts adapting, and the effects can change.

Why Understanding Medicinal Cannabis Effects Matters for Your Wellness

When you know how cannabis works in your body, you can:

1. Save Money: By using the right dose, you won’t waste cannabis or overspend on products that aren’t working effectively for you.
2. Get Better Results: Staying within the ideal range (we call it the therapeutic window) means you’re more likely to feel the benefits without unwanted side effects.
3. Reduce Risks: Balanced use prevents your body from adapting too much, which could make cannabis less effective over time.
4. Feel Empowered: Knowing what works for you helps you take control of your treatment, rather than guessing.
5. Work Better with Your Doctor: When you understand how cannabis affects you, you can share valuable feedback with your doctor. This helps refine your treatment plan and makes sure it’s tailored just for you.

For patients, recognising these changes is critical. Heavy, long-term use might lead to diminished effects and challenges in cognition or mood, making it essential to balance usage patterns.

How Understanding Cannabis Effects Can Clarify Research

You might also come across research or headlines about cannabis that seem contradictory. Some studies highlight its benefits, while others warn about potential risks. The biphasic effect is often the reason for this confusion. For example:

• Low doses in studies might show enhanced neuroplasticity and cognitive function.
• High doses might reveal reduced synaptic density or changes in brain activity.

Understanding the biphasic nature of cannabis, along with the acute vs chronic effects, helps you interpret research critically. It’s not about cannabis being good or bad – it’s about how it’s used and in what context. This also means you’re better equipped to discuss new findings with your doctor and decide what’s relevant for you.

Partnering with Your Doctor for Effective Medicinal Cannabis Use

Your doctor plays a critical role in helping you navigate the variable effects of cannabis. By working closely with a healthcare professional, you can:

• Receive Personalised Guidance: Every patient is different. Your doctor can help determine the right dose and frequency for your unique needs.
• Monitor Your Progress: Regular check-ins ensure that your treatment remains effective and aligned with your goals.
• Adjust as Needed: As your body changes or your health evolves, your doctor can help adapt your plan to keep cannabis working for you.
• Stay Informed: Your doctor can interpret the latest research and explain how it applies to your situation.

Actionable Tips to Optimise Your Medicinal Cannabis Treatment

Here’s how you can use this knowledge for your medicinal cannabis journey:

• Start Low, Go Slow: Begin with a small dose and increase gradually until you find what works best for you.
• Take Breaks: Periodic tolerance breaks help reset your body’s sensitivity and keep cannabis effective. Taking a minimum of 2-3 consecutive days off THC every 2-3 weeks is a good rule of thumb to follow.
• Track Your Response: Keep a journal of how you feel with different doses or products. This helps you and your doctor make informed adjustments.
• Stay Open to Change: As your body and needs evolve, your cannabis use might need to change too. Regular check-ins with your doctor can help.

You should feel empowered to discuss your usage habits openly with your doctor, ensuring that your treatment remains both effective and sustainable. Their knowledge about individual variability – such as body chemistry and medical conditions – will further support your health outcomes.

Conclusion: Enhancing Wellness Through Informed Use

Understanding the biphasic, acute, and chronic effects of cannabis isn’t just a scientific curiosity – it’s a practical way for you to take charge of your treatment. By using cannabis thoughtfully and in the right amounts, you can unlock its full potential while avoiding unnecessary risks or costs.

A patient-centred approach is crucial for making the most of your medicinal cannabis treatment. By actively participating in your healthcare decisions, together we can tailor your treatment to better fit your lifestyle and unique medical needs. This collaboration with your doctor creates a dynamic treatment plan that evolves with you, ensuring optimal results.

Book a follow-up today to speak with your doctor.

References

1. JAMA Psychiatry: Synaptic Density and Cannabis Use
2. Biphasic Effects of Cannabinoids in Anxiety Responses
3. Harvard Medical School: Brain Effects of Marijuana
4. Biphasic Effects of THC on Brain Reward Systems
5. Biphasic Effects of THC in Memory and Cognition